Methyl vinyl sulfone → HCID 59485596, compound

Participants

Reaction Conditions

Reaction Steps

To 1-(4-(4-chlorophenoxy)phenyl)-5-(3-(benzyloxy)phenyl)imidazolidin-2-one (Example 288) (200 mg, 0.42 mmol) in 5 mL DMF is added sodium hydride (19 mg, 0.47 mmol) followed by methyl vinyl sulfone (41 μL, 0.47 mmol). After 30 minute, the reaction is cooled to 0° C. and sat. ammonium chloride is added slowly to the reaction mixture. The reaction mixture is extracted with ethyl acetate (2×) and purified by flash chromatography gives 171 mg (71%) of the title compound. HPLC-MS calculated for C31H29ClN2O5S (M+H+): 577.2, found 577.2.

Provenance & Evidence