Cyanogen Bromide → HCID 87543951, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)—N-(1-(4-(4-chlorophenoxy)phenyl)-5-(3-(trifluoromethyl)-phenyl)imidazolidin-2-ylidene)cyanamide [prepared from Example 203] (15.0 mg, 0.033 mmol) in 1,4-dioxane (0.5 mL) is treated with excess BrCN and K2CO3. The reaction mixture is heated at 100° C. for 2 h, cooled, then quenched with H2O (5 mL) and extracted with EtOAc (3×3 mL). The combined organics are evaporated en vacuo and purified by preparatory LC/MS followed by preparatory TLC to provide the title compound; HPLC-MS calculated for C24H15ClF3N5O (M+H+) 482.1, found 482.1.

Provenance & Evidence