HuagongsheHuagongshe Chemistry Print Report · For research reference only
NADPH → HCID 66582536, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | NADPH | HCID 5884 | — |
| Reactant | HCID 66582496 | HCID 66582496 | — |
| Product | HCID 66582536 | HCID 66582536 | — |
Reaction Steps
2-methyl-4-(4-(phenylsulfonyl)-4′-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-3-biphenylyl)-3-butyn-2-ol. 1H NMR (400 MHz, CD3OD) δ 8.34 (d, J=8.2 Hz, 1H), 8.05 (d, J=7.8 Hz, 2H), 7.92-7.81 (m, 2H), 7.79-7.66 (m, 5H), 7.64-7.55 (m, 2H), 1.77 (s, 3H), 1.59 (s, 6H). m/z (ESI, +ve ion) 471.0 (M-OH)+. GK-GKRP EC50 (NADPH-coupled)=1.80 μM; GK-GKRP EC50 (LC MS/MS)=2.25 μM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431563B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4676cfe4e9e44621a127364176d81827 |
| Source note | uspto-grants-2013_04 |