NADPH → HCID 70655495, compound

Participants

Reaction Steps

(2S)-1,1,1-trifluoro-2-(4-((2S)-2-methyl-4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol. 1H NMR (300 MHz, MeOH) δ 7.72 (d, J=7.3 Hz, 2H), 7.62-7.50 (m, 3H), 7.35 (d, J=8.5 Hz, 2H), 6.81 (d, J=8.6 Hz, 2H), 3.51 (d, J=11.6 Hz, 1H), 3.34-3.26 (m, 3H), 3.15-3.01 (m, 1H), 2.69 (d, J=11.4 Hz, 1H), 2.53 (t, J=8.9 Hz, 1H), 1.57 (s, 3H), 0.98 (d, J=6.4 Hz, 3H). m/z (ESI, +ve ion) 429.0 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=3.12 μM; GK-GKRP EC50 (LC MS/MS)=4.01 μM

Provenance & Evidence