(S)-1-Boc-3-methylpiperazine → HCID 66582778, compound

HRID 1972379Notes

Reaction equation

HRID 1972379 reaction equation
[CH3:1][C@@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:3]1.Br[C:16]1[CH:21]=[CH:20][C:19]([C:22]([OH:28])([CH3:27])[C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=1.CC(C)([O-])C.[Na+].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC(C)C)=CC=CC=2OC(C)C)CCCCC1>O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(C)C=CC=CC=1>[CH3:1][C@@H:2]1[N:7]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([OH:28])([CH3:27])[C:23]([F:25])([F:26])[F:24])=[CH:18][CH:17]=2)[CH2:6][CH2:5][N:4]([C:8]([O:10][C:11]([CH3:13])([CH3:12])[CH3:14])=[O:9])[CH2:3]1

Participants

8

Reactant 4

HCID 7023035(S)-1-Boc-3-methylpiperazineHCID 162179852-Dicyclohexylphosphino-2',6'-diisopropoxybiphenylHCID 23676156Sodium t-butoxideHCID 583472902-(4-Bromophenyl)-1,1,1-trifluoropropan-2-ol

Product 1

HCID 66582778HCID 66582778, compoundYield 67.3%

Reagents, catalysts & solvents 3

HCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 962WaterSolventHCID 1140TolueneSolvent

Conditions

Temperature
100 °C

Procedure

A 100 mL round-bottomed flask was charged with tert-butyl (3S)-3-methyl-1-piperazinecarboxylate (10.0 g, 49.9 mmol), 2-(4-bromophenyl)-1,1,1-trifluoro-2-propanol (13.43 g, 49.9 mmol, Example 27, step 1), sodium tert-butoxide (10.56 g, 110 mmol) and 100 mL of toluene. To this was added dicyclohexyl(2′,6′-diisopropoxybiphenyl-2-yl)phosphine (RuPhos) (1.864 g, 3.99 mmol, Strem Chemical Inc, Newburyport, Mass.), tris(dibenzylideneacetone)dipalladium (0) (1.83 g, 2.00 mmol, Strem Chemical Inc, Newburyport, Mass.). The mixture was heated at 100° C. for 12 h then diluted with water (100 mL) and extracted with EtOAc (2×200 mL). The combined extracts were dried (MgSO4) and purified by column chromatography (330 g of silica, 0 to 50% EtOAc in hexanes) to give tert-butyl (3S)-3-methyl-4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate (13.05 g) as a white solid.

Workup

  1. extractionextracted with EtOAc (2×200 mL)
  2. dry with materialThe combined extracts were dried (MgSO4)
  3. custompurified by column chromatography (330 g of silica, 0 to 50% EtOAc in hexanes)

Sources & evidence

ORD record
ord-622873c19ee14dceb67b00f9c9790bb6
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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