NADPH → HCID 66582885, compound

Participants

Reaction Steps

(2R)-1,1,1-trifluoro-2-(4-((2S)-4-(2-furanylsulfonyl)-2-methyl-1-piperazinyl)phenyl)-2-propanol. 1H NMR (400 MHz, CD3OD) δ 8.14 (s, 1H), 7.74-7.71 (m, 1H), 7.46 (d, J=8.9 Hz, 2H), 6.94 (d, J=8.9 Hz, 2H), 6.74-6.72 (m, 1H), 4.08-4.01 (m, 1H), 3.64-3.57 (m, 1H), 3.42-3.33 (m, 2H), 3.24-3.15 (m, 1H), 2.93-2.87 (m, 1H), 2.77-2.69 (m, 1H), 1.68 (ms, 3H), 1.08 (d, J=9.0 Hz, 3H). m/z (ESI, +ve ion) 419.1 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=3.12 μM; GK-GKRP EC50 (LC MS/MS)=50 μM.

Provenance & Evidence