NADPH → HCID 86670313, compound

Participants

Reaction Steps

(2R)-1,1,1-trifluoro-2-(4-(4-(1,3-thiazol-2-ylsulfonyl)-1-piperazinyl)phenyl)-2-propanol. 1H NMR (400 MHz, CDCl3) δ 8.03 (d, J=3.1 Hz, 1H), 7.67 (d, J=3.1 Hz, 1H), 7.48 (d, J=8.8 Hz, 2H), 6.94 (d, J=9.0 Hz, 2H), 3.48-3.58 (m, 4H), 3.27-3.38 (m, 4H), 1.76 (s, 3H). m/z (ESI, +ve ion) 421.8 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=1.18 μM; GK-GKRP EC50 (LC MS/MS)=4.75 μM.

Provenance & Evidence