HuagongsheHuagongshe Chemistry Print Report · For research reference only
NADPH → HCID 66582528, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | NADPH | HCID 5884 | — |
| Reactant | HCID 70655536 | HCID 70655536 | — |
| Product | HCID 66582528 | HCID 66582528 | — |
Reaction Steps
(2R)-2-(4-((2S)-4-((5-amino-1,3,4-thiadiazol-2-yl)sulfonyl)-2-methyl-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol. 1H NMR (400 MHz, CD3OD) δ 7.47 (d, J=8.6 Hz, 2H), 6.98 (d, J=8.6 Hz, 2H), 4.10-4.03 (m, 1H), 3.80-3.74 (m, 1H), 3.57-3.51 (m, 1H), 3.42-3.36 (m, 1H), 3.29-3.17 (m, 2H), 3.15-3.07 (m, 1H), 1.68 (s, 3H), 1.10-1.06 (d, J=6.5 Hz, 3H). m/z (ESI, +ve ion) 452.1 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=3.04 μM; GK-GKRP EC50 (LC MS/MS)=5.62 μM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431563B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-5d7fff974589433e933630f52987457f |
| Source note | uspto-grants-2013_04 |