反应详情

A 250 mL round-bottomed flask was charged with methyl N-(tert-butoxycarbonyl)-3-(tetrahydro-2H-pyran-4-yl)-alanylglycinate (3.00 g, 8.71 mmol), 10 mL of CH2Cl2, and 5 mL of TFA. After 10 min, the mixture was concentrated then re-dissolved in MeOH (50 mL) and triethylamine (10 mL) and then heated at reflux for 18 h. After that time, the white precipitate formed was collected by filtration to give 3-(tetrahydro-2H-pyran-4-ylmethyl)-2,5-piperazinedione (1.44 g) as a white solid.

1. concentrationthe mixture was concentrated
2. dissolutionthen re-dissolved in MeOH (50 mL)
3. temperaturetriethylamine (10 mL) and then heated
4. temperatureat reflux for 18 h
5. customAfter that time, the white precipitate formed
6. filtrationwas collected by filtration