NADPH → HCID 86670315, compound

Participants

Reaction Steps

1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol. 1H NMR (400 MHz, CD3OD) δ 7.89 (d, J=4.9 Hz, 1H), 7.70-7.61 (m, 1H), 7.55 (d, J=9.0 Hz, 2H), 7.31-7.23 (m, 1H), 6.96 (d, J=9.2 Hz, 2H), 4.18 (br. s., 1H), 3.95-3.64 (m, 4H), 3.60-3.44 (m, 1H), 3.40-3.23 (m, 2H), 2.70 (dd, J=2.9, 11.7 Hz, 1H), 2.57 (dt, J=3.6, 11.4 Hz, 1H), 1.86-1.65 (m, 2H), 1.65-1.38 (m, 3H), 1.38-1.08 (m, 3H). m/z (ESI, +ve ion) 573.0 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=0.169 μM; GK-GKRP EC50 (LC MS/MS)=0.281 μM.

Provenance & Evidence