NADPH → HCID 86670316, compound

Participants

Reaction Steps

1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(3-methylbenzyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol hydrochloride. 1H NMR (400 MHz, CD3OD) δ 7.87-7.83 (m, 1H), 7.62-7.58 (m, 3H), 7.24-7.21 (m, 1H), 7.19-7.14 (m, 1H), 7.08-6.99 (m, 5H), 4.17-4.11 (m, 1H), 3.88-3.82 (m, 1H), 3.68-3.56 (m, 2H), 3.42-3.34 (m, 1H), 3.12-3.04 (m, 1H), 2.62-2.53 (m, 2H), 2.51-2.46 (m, 1H), 2.31 (s, 3H). m/z (ESI, +ve ion) 578.8 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=0.724 μM; GK-GKRP EC50 (LC MS/MS)=0.688 μM.

Provenance & Evidence