NADPH → HCID 86670320, compound

Participants

Reaction Steps

1,1,1,3,3,3-hexafluoro-2-(4-((2R)-2-(4-methylbenzyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol hydrochloride. 1H NMR (400 MHz, CD3OD) δ 7.86-7.83 (m, 1H), 7.61-7.56 (m, 3H), 7.24-7.20 (m, 1H), 7.13-7.07 (m, 4H), 7.05-7.00 (m, 2H), 4.15-4.08 (m, 1H), 3.86-3.81 (m, 1H), 3.66-3.55 (m, 2H), 3.41-3.33 (m, 1H), 3.10-3.03 (m, 1H), 2.61-2.53 (m, 2H), 2.51-2.46 (m, 1H), 2.29 (s, 3H). m/z (ESI, +ve ion) 578.8 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=2.50 μM; GK-GKRP EC50 (LC MS/MS)=2.62 μM.

Provenance & Evidence