反应详情

A 250 ml, round-bottomed flask was charged with methyl O-benzyl-L-serylglycinate trifluoroacetate (9.37 g, 24.64 mmol) and 3:1 MeOH/triethylamine (50 mL). The mixture was then heated to reflux for 16 h. The reaction was then cooled to room temperature, concentrated, and diluted with ice cold 50% aqueous EtOH (50 mL). The resulting precipitate was collected by filtration and dried under reduced pressure to give 3-(benzyloxymethyl)piperazine-2,5-dione (3.95 g) as a white solid.

1. temperatureThe mixture was then heated
2. temperatureto reflux for 16 h
3. concentrationconcentrated
4. additiondiluted with ice cold 50% aqueous EtOH (50 mL)
5. filtrationThe resulting precipitate was collected by filtration
6. customdried under reduced pressure