NADPH → HCID 70655253, compound

Participants

Reaction Steps

(2R)-1,1,1-trifluoro-2-(4-((2S)-2-((3-pyridinylmethoxy)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol; (2S)-1,1,1-trifluoro-2-(4-((2R)-2-((3-pyridinylmethoxy)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol; (2S)-1,1,1-trifluoro-2-(4-((2S)-2-((3-pyridinylmethoxy)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol. 1H NMR (400 MHz, CDCl3) δ 8.40-8.38 (m, 1H), 7.67-7.65 (m, 1H), 7.60-7.58 (m, 1H), 7.52-7.46 (m, 3H), 7.45-7.39 (m, 1H), 7.22-7.18 (m, 2H), 6.88-6.86 (m, 2H), 4.45-4.35 (m, 2H), 4.26-4.22 (m, 1H), 3.91-3.77 (m, 3H), 3.73-3.69 (m, 1H), 3.41-3.27 (m, 2H), 2.84-2.79 (m, 1H), 2.69-2.60 (m, 1H), 1.74 (s, 3H). m/z (ESI, +ve ion) 542.1 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=4.93 μM; GK-GKRP EC50 (LC MS/MS)=4.93 μM.

Provenance & Evidence