Triacetoxyperiodinane → 4-(2-Thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinecarbaldehyde

Participants

Reaction Steps

To a suspension of 1,1,1-trifluoro-2-(4-(2-(hydroxymethyl)-4-(thiophen-3-ylsulfonyl)piperazin-1-yl)phenyl)-2-propanol hydrochloride (50 mg, 0.103 mmol, Example 44) in CH2Cl2 (2.0 mL) at room temperature was added solid sodium bicarbonate (17.25 mg, 0.205 mmol) followed by Dess-Martin periodinane (47.9 mg, 0.113 mmol, Sigma-Aldrich, St. Louis, Mo.). The reaction was stirred at this temperature for 30 min and then filtered through a pad of Celite® (diatomaceous earth) eluting with CH2Cl2. The filtrate was concentrated to yield 4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinecarbaldehyde which was used without purification.

Provenance & Evidence