NADPH → HCID 70655613, compound

Participants

Reaction Steps

(2R)-1,1,1-trifluoro-2-(4-((2S)-2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol; (2S)-1,1,1-trifluoro-2-(4-((2R)-2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol; (2S)-1,1,1-trifluoro-2-(4-((2S)-2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol. 1H NMR (400 MHz, CD3OD) δ 7.89-7.86 (m, 1H), 7.65-7.63 (m, 1H), 7.46-7.41 (m, 2H), 7.27-7.24 (m, 1H), 6.93-6.89 (m, 2H), 4.09-4.03 (m, 1H), 3.99-3.94 (m, 1H), 3.79-3.72 (m, 1H), 3.60-3.55 (m, 4H), 3.50-3.41 (m, 1H), 3.25-3.12 (m, 1H), 2.78-2.71 (m, 1H), 2.68-2.46 (m, 4H), 2.37-2.30 (m, 2H), 2.28-2.21 (m, 1H), 1.67 (s, 3H). m/z (ESI, +ve ion) 519.8 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=0.230 μM; GK-GKRP EC50 (LC MS/MS)=0.355 μM.

Provenance & Evidence