Hydrochloric Acid → HCID 86670327, compound

Participants

Reaction Steps

HCl (4.0 M solution with 1,4-dioxane, 3.9 mL, 16 mmol) was added to a stirring solution of tert-butyl (3S)-3-ethyl-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate (0.71 g, 1.6 mmol) and CH2Cl2 (7.8 mL) at room temperature. After 18 h, the reaction mixture was concentrated to give 2-(4-((2S)-2-ethyl-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride (0.55 g) as a brown solid. The material was used in the next step without purification.

Provenance & Evidence