NADPH → HCID 70655547, compound

Participants

Reaction Steps

(2S)-1,1,1-trifluoro-2-(3-((3-methyl-3-oxetanyl)ethynyl)-4-(4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol. 1H NMR (400 MHz, CD3OD) δ 7.92 (dd, J=1.2, 5.1 Hz, 1H), 7.67 (dd, J=1.2, 3.7 Hz, 1H), 7.58 (d, J=2.0 Hz, 1H), 7.50 (s, 1H), 7.29 (dd, J=3.8, 5.0 Hz, 1H), 7.01 (d, J=8.6 Hz, 1H), 4.76 (d, J=5.5 Hz, 2H), 4.48 (d, J=5.5 Hz, 2H), 3.31-3.25 (m, 4H), 3.25-3.15 (m, 4H), 1.71-1.67 (m, 3H), 1.64 (s, 3H). m/z (ESI, +ve ion) 515.0 (M+H)+. GK-GKRP EC50 (NADPH-coupled)=2.90 μM; GK-GKRP EC50 (LC MS/MS)=2.80 μM.

Provenance & Evidence