反应详情

This compound was synthesized following the procedure outlined for Example 84. The reaction of ((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl methanesulfonate (Intermediate B) and 3-cyclopropylthiomorpholine 1,1-dioxide followed by purification via column chromatography on silica gel (0 to 75% EtOAc in hexanes) delivered 2-(4-((2S)-2-((3-cyclopropyl-1,1-dioxido-4-thiomorpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol as a mixture of four isomers.

1. customThis compound was synthesized
2. customfollowed by purification via column chromatography on silica gel (0 to 75% EtOAc in hexanes)
3. additionas a mixture of four isomers