Sodium Hydroxide → HCID 66582484, compound

Participants

Reaction Steps

A 25-mL round-bottomed flask was charged with (4-(((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)-3-morpholinyl)acetate (70 mg, 0.116 mmol, Example 113), is aqueous 10 M NaOH (0.5 mL, 5.00 mmol) and MeOH (5 mL) and stirred at room temperature for 2 h. The reaction was concentrated to give (4-(((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)-3-morpholinyl)acetic acid (65 mg) as a mixture of four isomers. This material was used crude in the next reaction.

Provenance & Evidence