HCID 66582509, compound → HCID 66582589, compound

Participants

Reaction Steps

In a 100 mL round bottomed flask a mixture of 2-(4-((2S)-2,4-dibenzyl-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol (355 mg, 0.781 mmol) and 10% Pd/C (83 mg) in EtOH (20 mL) was placed under a hydrogen atmosphere (1 atm) 16 h. The mixture was filtered through a pad of Celite® (diatomaceous earth) and then concentrated onto silica gel and purified via column chromatography (40 g, 0 to 10% MeOH in CH2Cl2) to give 2-(4-((2S)-2-benzyl-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol (0.210 g).

Provenance & Evidence