1-Pentyn-3-ol → HCID 86670380, compound

Participants

Reaction Steps

Following the procedure outlined for Example 152, 2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (Example 69) was coupled to 1-pentyn-3-ol (Aldrich, St. Louis, Mo.) to afford 1-(2-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-pentyn-3-ol as a mixture of enantiomers.

Provenance & Evidence