4-Methylpentyn-3-ol → HCID 86670381, compound

Participants

Reaction Steps

Following the procedure outlined for Example 152, 2-(3-bromo-4-(4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (Example 69) was coupled to 4-methyl-1-pentyn-3-ol (Aldrich, St. Louis, Mo.) to afford 4-methyl-1-(2-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-pentyn-3-ol as a mixture of enantiomers.

Provenance & Evidence