1-Pentyn-3-ol → HCID 86670386, compound

Participants

Reaction Steps

Following the procedure described for Example 152, 2-(3-bromo-4-(4-(phenylsulfonyl)piperidin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol was coupled to 1-pentyn-3-ol (Aldrich, St. Louis, Mo.) to afford 1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-(4-(phenylsulfonyl)piperidin-1-yl)phenyl)pent-1-yn-3-ol as a light yellow solid and a mixture of enantiomers.

Provenance & Evidence