4-(((2R)-1,4-dibenzyl-2-piperazinyl)methyl)-3-(1-methylethyl)-2-piperazinone → 3-(1-methylethyl)-4-((2R)-2-piperazinylmethyl)-2-piperazinone

Participants

Reaction Steps

A solution of 4-(((2R)-1,4-dibenzyl-2-piperazinyl)methyl)-3-(1-methylethyl)-2-piperazinone (0.414 g, 0.984 mmol) in ethanol (4.92 mL) was placed under an atmosphere of N2 and charged with 10% palladium on carbon (10% wt. (dry basis) on activated carbon, wet, Degussa type (0.314 g, 0.295 mmol, Sigma-Aldrich, St. Louis, Mo.)). The mixture was purged with hydrogen gas and stirred at room temperature under a hydrogen atmosphere (1 atm) for 72 h. The solids were then removed by filtering through a pad of Celite® (diatomaceous earth), rinsing with EtOH, the filtrate was concentrated, and the product was carried forward without further purification (238 mg).

Provenance & Evidence