Methanesulfonyl chloride → HCID 56932774, compound

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Reaction Steps

To a solution of 2-(4-((2S)-2-((cyclopropylamino)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol (0.130 g, 0.258 mmol, Example 199) in CH2Cl2 (5.0 mL) was added 4-dimethylaminopyridine (0.006 g, 0.052 mmol), methanesulfonyl chloride (0.059 g, 0.516 mmol) and Hünig's base (0.135 mL, 0.774 mmol). After 20 min at room temperature, the solvent was concentrated and the crude product was purified by column chromatography (40 g of silica gel, 10 to 30% acetone in hexanes) to give N-cyclopropyl-N-(((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)methanesulfonamide (0.100 g) as a mixture of two isomers.

Provenance & Evidence