HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutylamine → HCID 70656238, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutylamine | HCID 6558 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1,1,1-trifluoro-2-(4-((2S)-2-(((2-methylpropyl)amino)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol | HCID 66582727 | — |
| Reactant | ((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl methanesulfonate | HCID 86670301 | — |
| Product | HCID 70656238 | HCID 70656238 | — |
Reaction Steps
This compound was synthesized following the scheme described for Example 195. The reaction of ((2R)-4-(thiophen-2-ylsulfonyl)-1-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)piperazin-2-yl)methyl methanesulfonate (Intermediate B) and isobutyl amine (Aldrich, St. Louis, Mo.), followed by sulfonamide formation (using MsCl) delivered 1,1,1-trifluoro-2-(4-((2S)-2-(((2-methylpropyl)amino)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol as a mixture of two isomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431563B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d45fd6ffa79846b582e09fa4500e223a |
| Source note | uspto-grants-2013_04 |