Sodium Bicarbonate → 2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Participants

Reaction Conditions

Reaction Steps

A 5-mL vial was charged with 2-(4-((2S)-4-((5-nitro-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (0.060 g, 0.094 mmol, step 5), iron filings (0.0282 g, 0.505 mmol, Sigma-Aldrich, St. Louis, Mo.) and acetic acid (2 mL). The mixture was stirred at 50° C. for 40 min. Saturated aqueous NaHCO3 (20 mL) was added slowly and then the aqueous phase was extracted with EtOAc (2×20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by column chromatography (twice, 25 g of silica gel, 30 to 90% EtOAc in hexanes then 10 g of silica gel, 30 to 90% EtOAc in hexanes) to afford 2-(4-((2S)-4-((5-amino-2-thiophenyl)sulfonyl)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (0.0386 g) as a white solid.

Provenance & Evidence