HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalic Anhydride → 2-(2-Hydroxymethylindan-2-yl)-isoindole-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Reactant | (2-Amino-2,3-dihydro-1H-inden-2-yl)methanol | HCID 22080542 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(2-Hydroxymethylindan-2-yl)-isoindole-1,3-dione | HCID 68561206 | — |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
A mixture of (2-aminoindan-2-yl)methanol (0.407 g, 2.50 mmol) and phthalic anhydride (0.369 g, 2.50 mmol) is heated at 160° C. for 40 minutes. The reaction mixture is poured into water and extracted with chloroform. The organic phase is dried (Na2SO4) and evaporated to afford 2-(2-hydroxymethylindan-2-yl)-isoindole-1,3-dione, MH+294.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745462B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-9c2a51c334da45ef9b380da3998da7ac |
| Source note | uspto-grants-2010_06 |