HCID 66582371, compound → HCID 66582343, compound

HRID 1972647Notes

Reaction equation

HRID 1972647 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[CH:21][C:20]([C@:23]([OH:29])([CH3:28])[C:24]([F:27])([F:26])[F:25])=[CH:19][N:18]=3)[C@@H:13]([C:30]#[C:31][CH3:32])[CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.NC1N=CC(S(N2CCN(C3N=CC([C@@](O)(C)C(F)(F)F)=CN=3)[C@H](C#CC)C2)(=O)=O)=CC=1.NC1N=CC(S(N2CCN(C3N=CC([C@](O)(C)C(F)(F)F)=CN=3)[C@H](C#CC)C2)(=O)=O)=CC=1>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[CH:21][C:20]([C@@:23]([OH:29])([CH3:28])[C:24]([F:27])([F:26])[F:25])=[CH:19][N:18]=3)[C@@H:13]([C:30]#[C:31][CH3:32])[CH2:12]2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 66582371HCID 66582371, compoundHCID 66582418HCID 66582418, compoundHCID 66582565HCID 66582565, compound

Product 1

HCID 66582343HCID 66582343, compound

Procedure

(2R)-2-(2-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-5-pyrimidinyl)-1,1,1-trifluoro-2-propanol; (2S)-2-(2-((2R)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-5-pyrimidinyl)-1,1,1-trifluoro-2-propanol; and (2R)-2-(2-((2R)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-5-pyrimidinyl)-1,1,1-trifluoro-2-propanol.

Sources & evidence

ORD record
ord-42a1441230c74f8ea2fe5e2e88439837
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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