HCID 66582776, compound → HCID 66582471, compound

HRID 1972648Notes

Reaction equation

HRID 1972648 reaction equation
[C:1]1([C@@H:7]([N:9]([CH2:14][C@H:15]2[CH2:20][N:19]([S:21]([C:24]3[S:25][CH:26]=[CH:27][CH:28]=3)(=[O:23])=[O:22])[CH2:18][CH2:17][N:16]2[C:29]2[CH:34]=[CH:33][C:32]([C@@:35]([OH:41])([CH3:40])[C:36]([F:39])([F:38])[F:37])=[CH:31][CH:30]=2)[S:10]([CH3:13])(=[O:12])=[O:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1([C@H](N(C[C@H]2CN(S(C3SC=CC=3)(=O)=O)CCN2C2C=CC([C@](O)(C)C(F)(F)F)=CC=2)S(C)(=O)=O)C)C=CC=CC=1.C1([C@@H](N(C[C@H]2CN(S(C3SC=CC=3)(=O)=O)CCN2C2C=CC([C@](O)(C)C(F)(F)F)=CC=2)S(C)(=O)=O)C)C=CC=CC=1>>[C:1]1([C@H:7]([N:9]([CH2:14][C@H:15]2[CH2:20][N:19]([S:21]([C:24]3[S:25][CH:26]=[CH:27][CH:28]=3)(=[O:23])=[O:22])[CH2:18][CH2:17][N:16]2[C:29]2[CH:30]=[CH:31][C:32]([C@@:35]([OH:41])([CH3:40])[C:36]([F:38])([F:37])[F:39])=[CH:33][CH:34]=2)[S:10]([CH3:13])(=[O:12])=[O:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 66582776HCID 66582776, compoundHCID 66583175HCID 66583175, compoundHCID 66583362HCID 66583362, compound

Product 1

HCID 66582471HCID 66582471, compound

Procedure

N-((1S)-1-phenylethyl)-N-(((2R)-4-(2-thiophenylsulfonyl)-1-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)methanesulfonamide; N-((1R)-1-phenylethyl)-N-(((2R)-4-(2-thiophenylsulfonyl)-1-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)methanesulfonamide; and N-((1S)-1-phenylethyl)-N-(((2R)-4-(2-thiophenylsulfonyl)-1-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)methanesulfonamide

Sources & evidence

ORD record
ord-d7708cd88e8240caa436ec27559dd12e
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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