2-(4-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol → 1,1,1,3,3,3-Hexafluoro-2-(4-(2-((6-methoxy-2-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Participants

Reaction Conditions

Reaction Steps

To a 50-mL round-bottomed flask was added 3-((6-methoxy-2-pyridinyl)methyl)-1-(2-thiophenylsulfonyl)piperazine (115 mg, 0.325 mmol), 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (126 mg, 0.390 mmol, Bioorg. Med. Chem. Lett. 2002, 12, 3009), dicyclohexyl(2′,4′,6′-triisopropyl-[1′,1′-biphenyl]-2-yl)phosphine (RuPhos)(62 mg, 0.13 mmol, Strem, Newburyport, Mass.), tris(dibenzylideneacetone)dipalladium (30 mg, 0.033 mmol, Strem, Newburyport, Mass.) and sodium tert-butoxide (94 mg, 0.98 mmol, Aldrich, St. Louis, Mo.) in toluene (5 mL). The reaction mixture was stirred at 100° C. for 18 h and then allowed to cool to room temperature and then diluted with saturated NH4Cl (5 mL) and extracted with EtOAc (2×40 mL). The organic extract was washed with saturated NaCl (5 mL) and dried over Na2SO4. The solution was filtered and concentrated in vacuo to give the crude material as a light-yellow oil. The crude product was purified by silica gel chromatography, eluting with 30% EtOAc/hexanes to give 1,1,1,3,3,3-hexafluoro-2-(4-(2-((6-methoxy-2-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol (146 mg) as a light-yellow tar (mixture of enantiomers).

Provenance & Evidence