Diethylamine → HCID 86670434, compound

Participants

Reaction Conditions

Reaction Steps

A glass microwave reaction vessel was charged with 2-(3-bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (128 mg, 0.23 mmol, Example 69, step 2), 1-(trimethylsilyl)-1-propyne (0.173 mL, 1.16 mmol, Sigma-Aldrich, St. Louis, Mo.), diethylamine (48 μL, 0.46 mmol, Sigma-Aldrich, St. Louis, Mo.), bis(triphenylphosphine) palladium(II) dichloride (15 mg, 0.02 mmol, Strem Chemical Inc, Newburyport, Mass.), triphenylphosphine (12 mg, 0.05 mmol, Sigma-Aldrich, St. Louis, Mo.), copper iodide (9 mg, 0.05 mmol, Strem Chemical Inc, Newburyport, Mass.), and DMF (1 mL). The reaction mixture was purged with nitrogen for several minutes, and then stirred and heated in an Emrys Optmizer microwave reactor (Personal Chemistry, Biotage AB, Inc., Upssala, Sweden) at 120° C. for 30 min. The reaction was diluted with EtOAc (about 10 mL) and water (about 10 mL). The organic layer was separated and washed with water (10 mL), dried (Na2SO4), concentrated and purified column chromatography (12 g silica, 0 to 20% EtOAc in hexanes to afford 1,1,1,3,3,3-hexafluoro-2-(3-(1-propyn-1-yl)-4-(4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol (28 mg) as a white solid.

Provenance & Evidence