Triethylamine → HCID 86670442, compound

Participants

Reaction Conditions

Reaction Steps

In a 50-mL sealed vial, a mixture of (S)-3-(prop-1-yn-1-yl)-1-(thiophen-2-ylsulfonyl)piperazine (40 mg, 0.148 mmol), 2-(2-chloropyrimidin-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol (41.5 mg, 0.148 mmol), and triethylamine (30.9 μl, 0.222 mmol) in dioxane was heated to 100° C. for 16 h. Afterwards, the mixture was concentrated and the crude material was purified via column chromatography (about 40 g silica gel, 0% to 10% MeOH in CH2Cl2) to give the racemate of 1,1,1,3,3,3-hexafluoro-2-(2-((2S)-2-(1-propyn-1-yl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-5-pyrimidinyl)-2-propanol (18 mg) and 1,1,1,3,3,3-hexafluoro-2-(2-((2R)-2-(1-propyn-1-yl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-5-pyrimidinyl)-2-propanol (18 mg).

Provenance & Evidence