HCID 86670445, compound → HCID 86670444, compound

HRID 1972694Notes

Reaction equation

HRID 1972694 reaction equation
[F:1][C:2]([F:38])([F:37])[C@@:3]([C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][N:15]([S:18]([C:21]3[S:22][CH:23]=[CH:24][CH:25]=3)(=[O:20])=[O:19])[CH2:14][C@@H:13]2[CH2:26][N:27]2[CH2:32][CH2:31][NH:30][C@H:29]([C:33]([F:36])([F:35])[F:34])[CH2:28]2)=[CH:8][CH:7]=1)([OH:5])[CH3:4].FC(F)(F)[C@](C1C=CC(N2CCN(S(C3SC=CC=3)(=O)=O)C[C@@H]2CN2CCN[C@@H](C(F)(F)F)C2)=CC=1)(O)C.FC(F)(F)[C@@](C1C=CC(N2CCN(S(C3SC=CC=3)(=O)=O)C[C@@H]2CN2CCN[C@@H](C(F)(F)F)C2)=CC=1)(O)C>>[F:38][C:2]([F:1])([F:37])[C@:3]([C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][N:15]([S:18]([C:21]3[S:22][CH:23]=[CH:24][CH:25]=3)(=[O:19])=[O:20])[CH2:14][C@@H:13]2[CH2:26][N:27]2[CH2:32][CH2:31][NH:30][C@H:29]([C:33]([F:34])([F:35])[F:36])[CH2:28]2)=[CH:8][CH:7]=1)([OH:5])[CH3:4]

Participants

4

Reactant 3

HCID 86670445HCID 86670445, compoundHCID 86670446HCID 86670446, compoundHCID 86670447HCID 86670447, compound

Product 1

HCID 86670444HCID 86670444, compound

Procedure

(2R)-1,1,1-trifluoro-2-(4-((2S)-4-(2-thiophenylsulfonyl)-2-(((3S)-3-(trifluoromethyl)-1-piperazinyl)methyl)-1-piperazinyl)phenyl)-2-propanol; (2S)-1,1,1-trifluoro-2-(4-((2S)-4-(2-thiophenylsulfonyl)-2-(((3R)-3-(trifluoromethyl)-1-piperazinyl)methyl)-1-piperazinyl)phenyl)-2-propanol; and (2R)-1,1,1-trifluoro-2-(4-((2S)-4-(2-thiophenylsulfonyl)-2-(((3R)-3-(trifluoromethyl)-1-piperazinyl)methyl)-1-piperazinyl)phenyl)-2-propanol.

Sources & evidence

ORD record
ord-cfc01042cdfe49f3ba0d4829eaedfacc
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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