HCID 86670448, compound → HCID 86670449, compound

Participants

Reaction Steps

A 150-mL round-bottomed flask was charged with tert-butyl (3R)-3-((benzyloxy)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate (0.917 g, 1.67 mmol), palladium on activated carbon (10 wt %, wet, degussa type, 1.34 g, 0.632 mmol, Sigma-Aldrich, St. Louis, Mo.) and EtOH (15 mL). The reaction mixture was evacuated under vacuum and refilled with hydrogen (5 times). The mixture was hydrogenated under balloon pressure of hydrogen at 60° C. for 2 h. The catalyst was removed via filtration through a pad of filter agent. The filter cake was covered with sand and washed with EtOH. The filtrate was concentrated to give tert-butyl (3R)-3-(hydroxymethyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate (0.767 g) as a white solid.

Provenance & Evidence