Ammonium Hydroxide → HCID 86670456, compound

Participants

Reaction Conditions

Reaction Steps

A 2-mL vial was charged with 2-(4-((2R)-4-((6-chloro-3-pyridinyl)sulfonyl)-2-((phenylsulfonyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (0.026 g, 0.039 mmol) and ammonium hydroxide (30 wt %, 0.50 mL, 3.9 mmol) and EtOH (0.5 mL). The vial was sealed and the reaction mixture was stirred at 110° C. for 5 h. The reaction mixture was concentrated and purified by column chromatography (10 g of silica, 0-5% (2 M NH3 in MeOH) in DCM) to afford 2-(4-((2R)-4-((6-amino-3-pyridinyl)sulfonyl)-2-((phenylsulfonyl)methyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (0.0057 g) as a white solid.

Provenance & Evidence