7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine → HCID 58529615, compound

HRID 1972730Notes

Reaction equation

HRID 1972730 reaction equation
[NH2:1][C:2]1[C:7]2=[CH:8][CH:9]=[C:10]([C:11]3[CH2:12][CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15][CH:16]=3)[N:6]2[N:5]=[CH:4][N:3]=1.Br[C:25]1N2C(C(N)=NC=N2)=CC=1>>[NH2:1][C:2]1[C:7]2=[CH:8][CH:9]=[C:10]([C:11]3[CH2:12][CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15][CH:16]=3)[N:6]2[N:5]=[C:4]([CH3:25])[N:3]=1

Participants

3

Reactant 2

HCID 422813837-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amineHCID 59231991HCID 59231991, compound

Product 1

HCID 58529615HCID 58529615, compound

Procedure

The title compound was prepared in the same manner described for the preparation of tert-butyl 4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,6-dihydropyridine-1(2H)-carboxylate and substituting 7-bromo-2-methylpyrrolo[2,1-f][1,2,4]triazin-4-amine for 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine. 1H-NMR (CD3OD): δ 7.02 (s, 1 H), 6.83 (d, 1 H), 6.62 (d, 1 H), 4.13 (s, 2 H), 3.64 (s, 2 H), 2.62 (d, 2 H), 2.33 (s, 3 H), 1.49 (s, 9 H). MS: LC/MS (+esi), m/z=330 [M+H]. RT=2.47 min.

Sources & evidence

ORD record
ord-c954ceef91ca490a87c74702f28ef60d
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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