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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1972736Generated: October 30, 2026

Hydrochloric Acid → HCID 69303569, compound

https://huagongshe.com/reaction/1972736

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 58529587HCID 58529587—
SolventMethanolHCID 887—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 69303569HCID 69303569100%

Reaction Steps

To a suspension of tert-butyl 3-[4-amino-5-(2-benzyl-2H-indazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]piperidine-1-carboxylate in MeOH (8 mL) was added 4M HCl in dioxane (4 mL). The mixture was stirred at rt for 17 h. The mixture was concentrated to dryness to afford 1.5 g (100%) of the desired product. ES-MS m/z 424.21 [M+H]+, HPLC RT (min) 2.21.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08431695B2
Source datasetuspto-grants-2013_04
ORD IDord-ee6e882e9fb140dc836bdba78fea0a57
Source noteuspto-grants-2013_04