HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 69303569, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 58529587 | HCID 58529587 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 69303569 | HCID 69303569 | 100% |
Reaction Steps
To a suspension of tert-butyl 3-[4-amino-5-(2-benzyl-2H-indazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]piperidine-1-carboxylate in MeOH (8 mL) was added 4M HCl in dioxane (4 mL). The mixture was stirred at rt for 17 h. The mixture was concentrated to dryness to afford 1.5 g (100%) of the desired product. ES-MS m/z 424.21 [M+H]+, HPLC RT (min) 2.21.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431695B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ee6e882e9fb140dc836bdba78fea0a57 |
| Source note | uspto-grants-2013_04 |