Sodium borohydride → HCID 58529678, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3-[(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)carbonyl]azetidine-1-carboxylate (1.35 g, 4.25 mmol) in EtOH (25 mL) was added sodium borohydride (644 mg, 17.01 mmol). The mixture was stirred at 78° C. for 2 h. The reaction was quenched with the addition of H2O (20 mL). The resulting solid was removed by filtration and the filtrate was extracted with EtOAc (3×20 mL). The combined organics were washed with brine, dried (Na2SO4), and concentrated to dryness to afford 1.0 g (74%) of the desired product. ES-MS m/z 320.16 [M+H]+, HPLC RT (min) 2.02.

Provenance & Evidence