Water → HCID 58529400, compound

Participants

Reaction Steps

The product from step 4 (367 mg, 0.65 mmol) was dissolved in 4 mL of 1:1 EtOH:THF and 0.5 mL of water was added followed by the addition of 1 drop of concentrated aqueous HCl. The mixture was stirred for 1 hour (ppt formed) and the solid was collected by filtration, washed with THF and air dried overnight to give 286 mg (98%) of the title compound as a white solid. 1H-NMR (DMSO-d6) 9.00 (bs, 1H), 8.63 (s, 1H), 8.26 (s, 1H), 8.02, (s, 1H) 7.96-7.86 (m, 2H) 7.80 (s, 1H), 7.49 (t, 1H), 7.46-7.30 (m, 6H), 7.28 (d, 1H), 7.26 (bs, 1H), 5.72 (s, 2H), 4.60 (s, 2H); LC-MS [M+H]+=447.3, RT=2.72 min.

Provenance & Evidence