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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 197283Generated: October 26, 2026

Hydrochloric Acid → 2-(3-Bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanol

https://huagongshe.com/reaction/197283

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantTriethylamineHCID 8471—
ReactantEthyl AcetateHCID 8857—
Reactant1,4-DioxaneHCID 31275—
Reactant2-Thiophenesulfonyl chlorideHCID 85518—
ReactantTert-butyl 4-(2-bromo-4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylateHCID 66582356—
Product2-(3-Bromo-4-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)-1,1,1-trifluoro-2-propanolHCID 66582913—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
ORD IDord-eadf43211b30444da82d6d4282fb918d
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (6/10)