3,3-Difluoropyrrolidine → HCID 58529491, compound

Participants

Reaction Steps

5-(2-benzyl-2H-indazol-6-yl)-7-[1-(chloroacetyl)pyrrolidin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine (100 mg, 0.206 mmol) was reacted with 3,3-difluoropyrrolidine (44 mg, 0.412 mmol) using the procedure of Example 132 to yield 100 mg (87%) of title compound. 1H NMR (300 MHz, DMSO-d6) δ 8.53 (s, 1 H), 7.91 (s, 1 H), 7.80 (d 1 H), 7.67 (m, 3 H), 7.38 (m, 4 H), 7.11 (d, 1 H), 6.63 (d, 1H), 5.63 (s, 2 H), 3.95-3.10 (m, 11 H), 3.05-2.60 (m, 4 H), 2.50-2.05 (m, 2 H); ES-MS m/z 557.3 [M+H]+, HPLC RT (min) 2.56.

Provenance & Evidence