Cyclopentanone → HCID 58529485, compound

Participants

Reaction Steps

Using a procedure similar to that of Example 111 with 7-(4-Aminomethyl-phenyl)-5-(2-benzyl-2H-indazol-6-yl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine and cyclopentanone as starting materials, 29.3 mg (12%) of the desired product was isolated. 1H NMR (300 MHz, DMSO-d6) δ 8.80 (s, 1 H), 8.05 (d, 2H), 8.0 (s, 1 H), 7.90 (d, 1 H), 7.70 (s, 1 H), 7.60-7.40 (m, 7 H), 7.25 (d, 1 H), 7.20 (s, 1 H), 5.70 (s, 2 H), 3.75 (s, 2 H) 3.00 (m, 1 H), 2.80-2.70 (m, 4 H), 2.50-2.40 (m, 4H); ES-MS m/z 514.16 [M+H]+, HPLC RT (min) 2.62.

Provenance & Evidence