Piperidine → 5-(2-Benzyl-2H-indazol-6-yl)-7-(4-piperidin-1-ylmethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine

Participants

Reaction Steps

Using a procedure similar to that of Example 282 (step 2) with 5-(2-benzyl-2H-indazol-6-yl)-7-(4-bromomethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine and piperidine as starting materials, 12 mg (5%) of the desired product was isolated. 1H NMR (300 MHz, DMSO-d6) δ 8.80 (s, 1 H), 8.05 (d, 2 H), 8.0 (s, 1 H), 7.90 (d, 1 H), 7.70 (s, 1 H), 7.60-7.40 (m, 7 H), 7.25 (d, 1 H), 7.20 (s, 1 H), 5.70 (s, 2 H), 3.50 (s, 2 H) 2.30 (m, 4 H), 1.80 (m, 2 H), 1.55 (m, 4 H), 1.40 (m, 2 H); ES-MS m/z 514.04 [M+H]+, HPLC RT (min) 2.34.

Provenance & Evidence