HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethylpiperazine → 5-(2-Benzyl-2H-indazol-6-yl)-7-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethylpiperazine | HCID 79196 | — |
| Reactant | 5-(2-benzyl-2H-indazol-6-yl)-7-(4-bromomethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine | HCID 69303291 | — |
| Product | 5-(2-Benzyl-2H-indazol-6-yl)-7-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine | HCID 58529919 | 1.2% |
Reaction Steps
Using a procedure similar to that of Example 282, step 2, with 5-(2-benzyl-2H-indazol-6-yl)-7-(4-bromomethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine and 1-ethyl-piperazine as starting materials, 3.4 mg (1.2%) of the desired product was isolated. 1H NMR (300 MHz, DMSO-d6) δ 8.80 (s, 1 H), 8.05 (d, 2 H), 8.00 (s, 1 H), 7.90 (d, 1 H), 7.70 (s, 1 H), 7.60-7.40 (m, 7 H), 7.25 (d, 1 H), 7.20 (s, 1 H), 5.70 (s, 2 H), 3.50 (s, 2 H), 2.40-2.20 (m, 10), 1.0 (t, 3 H); ES-MS m/z 543.01 [M+H]+, HPLC RT (min) 2.28.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431695B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-120f9ca80c6d4a8a94faac9c138eef5e |
| Source note | uspto-grants-2013_04 |