3,3-Difluoropyrrolidine → 5-(2-Benzyl-2H-indazol-6-yl)-7-[4-(3,3-difluoro-pyrrolidin-1-ylmethyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine

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Reaction Steps

Using a procedure similar to that of Example 282, step 2, with 5-(2-benzyl-2H-indazol-6-yl)-7-(4-bromomethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine and 3,3-difluoro-pyrrolidine as starting materials, 6.3 mg (2.4%) of the desired product was isolated. 1H NMR (300 MHz, DMSO-d6) δ 8.80 (s, 1 H), 8.05 (d, 2 H), 8.0 (s, 1 H), 7.90 (d, 1 H), 7.70 (s, 1 H), 7.60-7.40 (m, 7 H), 725 (d, 1 H), 7.20 (s, 1 H), 5.70 (s, 2 H), 3.70 (s, 2 H), 3.2 (m, 2 H), 2.70 (m, 2 H), 2.20 (s, 2 H); ES-MS m/z 536.22 [M+H]+, HPLC RT (min) 2.52.

Provenance & Evidence