HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiomorpholine → 5-(2-Benzyl-2H-indazol-6-yl)-7-(4-thiomorpholin-4-ylmethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 5-(2-benzyl-2H-indazol-6-yl)-7-(4-bromomethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine | HCID 69303291 | — |
| Product | 5-(2-Benzyl-2H-indazol-6-yl)-7-(4-thiomorpholin-4-ylmethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine | HCID 58529335 | 6% |
Reaction Steps
Using a procedure similar to that of Example 282, step 2, with 5-(2-benzyl-2H-indazol-6-yl)-7-(4-bromomethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine and thiomorpholine as starting materials, 19 mg (6%) of the desired product was isolated. 1H NMR (300 MHz, DMSO-d6) δ 8.60 (s, 1 H), 8.05 (d, 2 H), 8.0 (s, 1 H), 7.90 (d, 1 H), 7.70 (s, 1 H), 7.60-7.40 (m, 7 H), 7.25 (d, 1 H), 7.20 (s, 1 H), 5.70 (s, 2 H), 3.60 (d, 2 H), 2.6 (t, 8 H); ES-MS m/z 532.07 [M+H]+, HPLC RT (min) 2.34.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431695B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-6ba99ed5681e4842abbb6577761524ff |
| Source note | uspto-grants-2013_04 |