Trifluoroacetic acid → HCID 58529336, compound

Participants

Reaction Steps

To a suspension of 7-[4-amino-5-(2-benzyl-2H-indazol-6-yl)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (2.7 g, 4.7 mmol) in DCM (17 mL) was added TFA (8.6 mL), and the reaction mixture was stirred at rt overnight. The reaction mixture was concentrated and ethyl acetate was added. Saturated, aqueous NaHCO3 was added until the pH was basic. Yellow gum formed in the wall of glass, it was dried in vacuum oven overnight and the title product was obtained as light yellow solid, 2.2 g (98%). 1H NMR (300 MHz, DMSO-d6) δ 8.60 (s, 1 H), 8.05 (d, 2 H), 8.0 (s, 1 H), 7.90 (d, 1 H), 7.70 (s, 1 H), 7.60-7.40 (m, 7 H), 7.25 (d, 1 H), 7.20 (s, 1 H), 5.70 (s, 2 H), 4.1 (m, 2 H), 3.2 (m, 2 H), 2.80 (m, 2 H); ES-MS m/z 472.29 [M+H]+, HPLC RT (min) 2.22.

Provenance & Evidence