2-benzyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-Indazole → HCID 58529931, compound

Participants

Reaction Steps

Using the procedures described in Steps 1-6 of Intermediate SS and substituting 2-phenyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-Indazole for Intermediate C, 5-(2-phenyl-2H-indazol-6-yl)-7-piperidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine hydrochloride was prepared. The salt was dissolved in 3:1 CHCl3/isopropanol (25 mL). The mixture was washed with saturated, aqueous NaHCO3 (25 mL), brine, dried (Na2SO4) and concentrated to dryness to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 9.19 (s, 1 H), 8.12 (d, 2 H), 7.80-8.02 (m, 2 H), 7.71 (s, 1 H), 7.54-7.79 (m, 2 H), 7.39-7.54 (m, 1 H), 7.25 (d, 1 H), 6.67 (s, 1 H), 3.19-3.48 (m, 3 H), 2.93-3.05 (m, 1 H), 2.48-2.73 (m, 2 H), 2.01-2.17 (m, 1 H), 1.46-1.82 (m, 2 H); ES-MS m/z 410.36 [M+H]+, HPLC RT (min) 2.05.

Provenance & Evidence